반응 #742121

반응 방정식

Bromine

1,2-bis (diphenyl)phosphinoethane

5-(2-napthyl)pentan-1-ol

→

title compound

1-Bromo-5-(2-napthyl)-pentane

용매

ethyl ether pentane

dichloromethane

dichloromethane

dichloromethane

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후처리

1. 1
   여과filtered through a thin pad of celite
2. 2
   기타the solvent evaporated
3. 3
   기타The resulting oil was purified by flash chromatography (hexane)

실험 절차

Bromine (a 2M solution in dichloromethane; 955 mg, 5.97 mmol) was added to a solution of 1,2-bis (diphenyl)phosphinoethane (1.16 g, 2.99 mmol) in dichloromethane (15 ml) at 0°. A solution of 5-(2-napthyl)pentan-1-ol (513 mg, 2.39 mmol) in dichloromethane (5 ml) was added to the 0° solution. The solution was warmed to room temperature and stirred for 1.5 hours. The solution was diluted with ethyl ether/pentane (1:3), filtered through a thin pad of celite and the solvent evaporated. The resulting oil was purified by flash chromatography (hexane) giving the title compound as a colorless oil.

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