반응 #74188

반응 방정식

3-(2-chloro-acetyl)bicyclo[3.2.1]octane-2,4-dione

4-chloro-thiobenzamide

→

3-[2-(4-chloro-phenyl)thiazol-4-yl]bicyclo[3.2.1]octane-2,4-dione

수율 53.3%

용매

toluene

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도under reflux overnight
3. 3
   기타Therefore, the reaction mixture was evaporated to a black gum
4. 4
   기타the gum was absorbed onto silica
5. 5
   기타purified by flash chromatography
6. 6
   세척eluting with a gradient of hexane/ethyl acetate

실험 절차

3-(2-chloro-acetyl)bicyclo[3.2.1]octane-2,4-dione (3.16 g, 14.7 mmol) and 4-chloro-thiobenzamide (2.53 g, 14.7 mmol) are mixed together in toluene (50 ml) and heated under reflux overnight. Therefore, the reaction mixture was evaporated to a black gum and the gum was absorbed onto silica and purified by flash chromatography eluting with a gradient of hexane/ethyl acetate to give 3-[2-(4-chloro-phenyl)thiazol-4-yl]bicyclo[3.2.1]octane-2,4-dione (2.6 g).

출처