반응 #741505

반응 방정식

S-atenolol

p-toluic acid

→

S-atenolol toluate

용매

acetone

반응 조건

후처리

1. 1
   온도by heating
2. 2
   기타The precipitated crystals are separated by filtration
3. 3
   농축the filtrate is concentrated under reduced pressure

실험 절차

S-atenolol (optical purity, 91 % ee, 4.43 g) and p-toluic acid (2.28 g) are dissolved in acetone (300 ml) by heating, and the mixture is allowed to stand overnight at room temperature. The precipitated crystals are separated by filtration, and the filtrate is concentrated under reduced pressure to give S-atenolol toluate having an optical purity of 98.8% ee (5.01 g).

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