반응 #741237

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3-fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid

2-methylamino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethanol

→

3-Fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid-[2-hydroxy-2-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethyl-N-methyl-amide]

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후처리

1. 1
   기타the crude product is purified by chromatography on silica gel with ethyl acetate/hexane
2. 2
   기타4.93 g=76.3% of the theoretical yield
3. 3
   기타is obtained as an amorphous solid

실험 절차

Analogously to Example 22(a), 4.31 g (15 mmol) of 3-fluoro-6-(trifluoromethylsulfamoyl)-benzoic acid is reacted with 3.22 g (20 mmol) of 2-methylamino-1-(2,2-dimethyl-1,3-dioxolan-4-yl)-ethanol and the crude product is purified by chromatography on silica gel with ethyl acetate/hexane. 4.93 g=76.3% of the theoretical yield is obtained as an amorphous solid.

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