반응 #74058

반응 방정식

2,3-dichloropyrazine

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthonitrile

sodium carbonate

→

4-(3-chloropyrazin-2-yl)-1-naphthonitrile

용매

dioxane

반응 조건

후처리

1. 1
   온도The reaction mixture cooled to room temperature
2. 2
   세척washed with water
3. 3
   추출extracted with ethyl acetate
4. 4
   기타purified by chromatography

실험 절차

A mixture of 2,3-dichloropyrazine (2.98 g, 2 mmol), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthonitrile (0.558 mmol, 2 mmol) palladium tetrakis triphenylphoshine (0.069 g, 0.06 mmol) and aqueous sodium carbonate solution (2M, 3 mL, 6 mmol) in dioxane (7 mL) was heated to 80° C. for 12 hours. The reaction mixture cooled to room temperature, washed with water, extracted with ethyl acetate and purified by chromatography to yield 4-(3-chloropyrazin-2-yl)-1-naphthonitrile (0.36 g, 68%).

출처