반응 #73984
ord-b972cb7c15c5458b950f4d2b4e5536a5
반응 방정식
methacryloyl chloride
trimethylsilyl propyn-1-ol
Et3N
→
2-Methyl-acrylic acid 3-trimethylsilanyl-prop-2-ynyl ester
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타Any precipitated ammonium salts can be removed by filtration, and volatile components
- 2기타can be removed under reduced pressure
- 3기타The crude product is then purified by flash chromatography
실험 절차
A solution of trimethylsilyl propyn-1-ol (1 g, 7.8 mmol) and Et3N (1.4 mL, 10 mmol) in Et2O (10 mL) is cooled to −20° C. and a solution of methacryloyl chloride (0.9 mL, 9.3 mmol) in Et2O (5 mL) is added dropwise over 1 h. The mixture is stirred at this temperature for 30 min, and then allowed to warm to ambient temperature overnight. Any precipitated ammonium salts can be removed by filtration, and volatile components can be removed under reduced pressure. The crude product is then purified by flash chromatography.