반응 #73904
ord-d1a8431d8cb34cfeb130d26feef503b6
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The organic phase was separated
- 2세척washed with brine
- 3건조dried over anhydrous MgSO4
- 4기타The solvent was evaporated under reduced pressure at room temperature
- 5세척eluted with diethyl ether
실험 절차
5-Bromobenzofuran-2-carboxylic acid (4.68 g) was suspended in carbon tetrachloride (150 ml) and water (50 ml). To this was added sodium bicarbonate (3.36 g), followed by Selectflor (7.1 g) and the reaction mixture was stirred rapidly for 20 hours. The reaction mixture was diluted with dichloromethane and 2N sodium hydroxide solution. The organic phase was separated, washed with brine and dried over anhydrous MgSO4. The solvent was evaporated under reduced pressure at room temperature. The residue was applied to a silica cartridge (20 g) and eluted with diethyl ether. This gave 5-bromo-2-fluoro-1-benzofuran (1.4 g).