반응 #7389

반응 방정식

5-chloro-1-benzofuran-2-carboxylic acid

→

title compound

5-Chloro-1-benzofuran

용매

1-methyl-2-pyrrolidinone

반응 조건

후처리

1. 1
   온도The reaction vessel was cooled to room temperature
2. 2
   기타the combined mixtures partitioned between water and diethyl ether
3. 3
   세척The organic layer was washed with water and brine
4. 4
   건조dried (over magnesium sulphate)
5. 5
   농축concentrated under reduced pressure

실험 절차

To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.

출처