반응 #738031

반응 방정식

6-bromo-2-naphthol

6-bromoheptane

potassium iodide

potassium carbonate

→

6-bromo-2-heptyloxynaphthalene

용매

dimethyl sulfoxide

반응 조건

후처리

1. 1
   기타activated at 80° C. in high vacuum
2. 2
   온도It is then cooled
3. 3
   기타is partitioned between ethyl acetate and water
4. 4
   세척the organic phase is washed several times with water
5. 5
   건조dried over magnesium sulfate
6. 6
   여과filtered
7. 7
   기타evaporated down
8. 8
   기타toluene and subsequent crystallization from toluene/hexane (8:1)

실험 절차

A mixture of 5 g of 6-bromo-2-naphthol, 50 ml of dimethyl sulfoxide, 3.9 ml of 6-bromoheptane, 7.1 g of potassium iodide and 7.1 g of milled potassium carbonate activated at 80° C. in high vacuum is heated to 65° C. for 16 hours. It is then cooled and is partitioned between ethyl acetate and water and the organic phase is washed several times with water, dried over magnesium sulfate, filtered and evaporated down. Chromatography of the residue over 200 g of silica gel using toluene and subsequent crystallization from toluene/hexane (8:1) give 6-bromo-2-heptyloxynaphthalene.

출처