반응 #73673

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2-amino-N-(2-cyanoethyl)-4-methylthiazole-5-carboxamide

2-amino-N-ethyl-4-methylthiazole-5-carboxamide

4-benzylbenzoyl chloride

→

title compound

2-(4-Benzylbenzamido)-N-(2-cyanoethyl)-4-methylthiazole-5-carboxamide

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실험 절차

Following the procedure as described in Example 20, making variation only as required to use 2-amino-N-(2-cyanoethyl)-4-methylthiazole-5-carboxamide to replace 2-amino-N-ethyl-4-methylthiazole-5-carboxamide to react with 4-benzylbenzoyl chloride, the title compound was obtained; 1H NMR (CD3OD, 400 MHz) δ 7.90 (d, J=8.1 Hz, 2H), 7.35 (d, J=8.6 Hz, 2H), 7.27-7.10 (m, 5H), 4.03 (s, 2H), 3.54 (t, J=6.6 Hz, 2H), 2.73 (t, J=6.6 Hz, 2H), 2.54 (s, 3H), 2.32 (s, 1H); MS (ES+) m/z 405 (M+1).

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