반응 #73607

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2,2-dimethylpropionyl chloride

2-amino-4-methylthiazole-5-carboxylic acid benzylamide

→

title compound

수율 23.0%

2-(2,2-Dimethylpropionylamino)-4-methylthiazole-5-carboxylic Acid Benzylamide

수율 23.0%

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실험 절차

Following the procedure as described in Example 2, making variations only as required to use 2,2-dimethylpropionyl chloride in place of benzoyl chloride to react with 2-amino-4-methylthiazole-5-carboxylic acid benzylamide, the title compound was obtained as a white solid in 23% yield; 1H NMR (CDCl3, 300 MHz) δ 8.85 (s, br, 1H), 7.36-7.25 (m, 5H), 5.91 (s, br, 1H), 4.56 (d, J=5.8 Hz, 2H), 2.60 (s, 3H), 1.27 (s, 9H); MS (ES+) m/z 332.0 (M+1).

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