반응 #73588

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4-chlorobenzylamine

benzylamine

2-amino-4-methylthiazole-5-carboxylic acid

→

title compound

수율 15.0%

2-Amino-4-methylthiazole-5-carboxylic Acid 4-Chlorobenzylamide

수율 15.0%

반응 조건

후처리

1. 1
   기타as described in Preparation 1

실험 절차

Following the procedure as described in Preparation 1, making variation only as required to use 4-chlorobenzylamine to replace benzylamine to react with 2-amino-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a white solid in 15% yield; 1H NMR (CD3OD, 300 MHz) δ 7.26-7.32 (m, 4H), 4.41 (s, 2H), 2.38 (s, 3H). MS (ES+) m/z 282.1 (M+1).

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