반응 #735834

반응 방정식

sulfuric acid

α-(3-methyl-phenyl)-2-piperidino-benzyl alcohol

ethyl 4-cyanomethyl-benzoate

→

Ethyl 4-{N-[α-[3-methyl-phenyl)-2-piperidino-benzyl]-aminocarbonylmethyl}-benzoate

용매

o-dichlorobenzene

o-dichlorobenzene

반응 조건

후처리

1. 1
   workup.ADDITIONthe mixture was poured onto ice water
2. 2
   추출extracted once with ether
3. 3
   추출extracted with chloroform
4. 4
   추출The chloroform extract
5. 5
   농축was concentrated by evaporation
6. 6
   기타the residue was recrystallized from ethanol

실험 절차

A mixture of 0.22 gm (0.8 m mol) of α-(3-methyl-phenyl)-2-piperidino-benzyl alcohol and 0.15 gm (0.8 m mol) of ethyl 4-cyanomethyl-benzoate in 2 ml of o-dichlorobenzene was added dropwise, at ambient temperature, to 1.5 ml of o-dichlorobenzene and 1.5 ml of concentrated sulfuric acid. After stirring for two hours, the mixture was poured onto ice water, extracted once with ether, made alkaline with dilute sodium hydroxide solution, and extracted with chloroform. The chloroform extract was concentrated by evaporation, and the residue was recrystallized from ethanol.

출처