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4-[(1-(2-piperidinophenyl)-ethyl)-aminocarbonylmethyl]-benzaldehyde

sodium hydroxide

→

4-[(1-(2-Piperidino-phenyl)-1-ethyl)-aminocarbonylmethyl]-benzoic acid

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후처리

1. 1
   추출subsequent acidification with 2N sulfuric acid at a pH of 5, extraction
2. 2
   기타with ethyl acetate, and purification by column chromatography on silica gel (toluene/acetone=1:1)

실험 절차

The above compound was prepared from 4-[(1-(2-piperidinophenyl)-ethyl)-aminocarbonylmethyl]-benzaldehyde by heating with silver oxide in the presence of 1N sodium hydroxide solution for 20 minutes in a steam bath, subsequent acidification with 2N sulfuric acid at a pH of 5, extraction with ethyl acetate, and purification by column chromatography on silica gel (toluene/acetone=1:1).

출처