반응 #735810

반응 방정식

4-[(1-(2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid benzyl ester

hydrogen

→

4-[(1-(2-Piperidino-phenyl)-1-ethyl)-aminocarbonylmethyl]-benzoic acid

용매

ethanol

반응 조건

후처리

1. 1
   여과After five hours the catalyst was filtered off over celite
2. 2
   기타the filtrate was evaporated in vacuo
3. 3
   기타The evaporation residue was recrystallized from ethanol/water (8:2)

실험 절차

A quantity of 0.46 gm (1 mmol) of 4-[(1-(2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid benzyl ester in 20 ml of ethanol was hydrogenated at 0.25 gm of palladium/charcoal at 50° C. and a hydrogen pressure of 5 bar. After five hours the catalyst was filtered off over celite, and the filtrate was evaporated in vacuo. The evaporation residue was recrystallized from ethanol/water (8:2).

출처