반응 #73535

ord-48a7993569234b09b01c2e162858ac2c

반응 방정식

CCN(c1ccccc1)S(=O)(=O)c1ccc(-n2[nH]c(C)c(Cc3cccc(N(C)C)c3)c2=O)nc1
4
CCN(c1ccccc1)S(=O)(=O)c1ccc(-n2[nH]c(C)c(Cc3cccc(N(C)C)c3)c2=O)nc1
6-{4-[3-(dimethylamino)benzyl]-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl}-N-ethyl-N-phenylpyridine-3-sulfonamide
O=S(=O)(N[C@@H]1CC[C@H](COCc2ccccc2)C1)c1ccc(Cl)nc1
N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloropyridine-3-sulfonamide
CI
methyl iodide
→
CN([C@@H]1CC[C@H](COCc2ccccc2)C1)S(=O)(=O)c1ccc(Cl)nc1
N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloro-N-methylpyridine-3-sulfonamide
수율 86.0%

반응물

CCN(c1ccccc1)S(=O)(=O)c1ccc(-n2[nH]c(C)c(Cc3cccc(N(C)C)c3)c2=O)nc1
4
CCN(c1ccccc1)S(=O)(=O)c1ccc(-n2[nH]c(C)c(Cc3cccc(N(C)C)c3)c2=O)nc1
6-{4-[3-(dimethylamino)benzyl]-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl}-N-ethyl-N-phenylpyridine-3-sulfonamide
O=S(=O)(N[C@@H]1CC[C@H](COCc2ccccc2)C1)c1ccc(Cl)nc1
N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloropyridine-3-sulfonamide
CI
methyl iodide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

According to process 23.2, starting with 0.66 g of 4 N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloropyridine-3-sulfonamide and 0.22 mL of methyl iodide, 0.58 g of N-{(1R,3S)-3-[(benzyloxy)methyl]cyclopentyl}-6-chloro-N-methylpyridine-3-sulfonamide is obtained in the form of an oil.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08541455B2uspto-grants-2013_09