반응 #73530
ord-524d5b8a89904105974cb1f5b6ff1260
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반응물
시약
반응 조건
후처리
- 1세척washed successively with saturated NaHCO3 solution (30 mL) and brine (30 mL)
- 2건조dried over Na2SO4
- 3농축concentrated under reduced pressure
- 4기타purified by chromatography on a column of silica gel
- 5세척eluting with a 9/1 DCM/MeOH mixture
실험 절차
To a solution of 150 mg (0.27 mmol) of 6-(4-benzyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-N-[3-(benzyloxy)propyl]-N-cyclopentylpyridine-3-sulfonamide in 2 mL of DCM is added dropwise, at −78° C. under argon, 0.82 mL (0.82 mmol) of boron tribromide (1M in DCM). Stirring is continued for 1 hour at −78° C., and 2 mL of MeOH are then added at 0° C. The medium is taken up in 40 mL of DCM, washed successively with saturated NaHCO3 solution (30 mL) and brine (30 mL), dried over Na2SO4 and then concentrated under reduced pressure and purified by chromatography on a column of silica gel, eluting with a 9/1 DCM/MeOH mixture. 106 mg of 6-(4-benzyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-N-cyclopentyl-N-(3-hydroxypropyl)pyridine-3-sulfonamide are thus obtained in the form of a powder.