반응 #735289

반응 방정식

ether

6-chloro-2'-(N-methylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

iodomethane

→

product

수율 99.0%

6-Chloro-2'-(N,S-dimethylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)isoquinoline] hydroiodide

수율 99.0%

용매

methanol

ethanol

반응 조건

후처리

1. 1
   온도under reflux for four hours
2. 2
   기타Removal of solvents in vacuo
3. 3
   기타yields a solid which

실험 절차

A solution of 6-chloro-2'-(N-methylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (12.0 g) and iodomethane (7.4 g) in methanol (150 ml) and ethanol (100 ml) is heated under reflux for four hours. Removal of solvents in vacuo yields a solid which, upon trituration with ether, yields product as a solid (16.4 g, 99%). An analytical sample is recrystallized from ethyl acetate/methanol to yield a white solid, 181°-182° (dec.).

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