반응 #735287
ord-74b9e90e1e3b4c899c087c9c94ffcc05
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반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with water (2X), saturated sodium chloride solution
- 2건조dried over anhydrous magnesium sulfate
- 3여과After filtering
- 4기타the solvent is removed
- 5기타to yield an oil which
실험 절차
To a cooled solution of 6-chlorospiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (6.0 g) and triethylamine (2.4 g) in dichloromethane (50 ml) is slowly added dropwise propionyl chloride (2.3 g) in dichloromethane (20 ml). The reaction mixture is stirred for 18 hours at ambient temperature, washed with water (2X), saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtering, the solvent is removed to yield an oil which, upon trituration with hexane/ether, yields product as a white solid (6.6 g, 92%). An analytical sample is recrystallized from hexane to yield a white solid, mp 106°-107°.