반응 #735284

반응 방정식

2'-(N-methylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

iodomethane

→

solid

수율 93.8%

2'-(N,S-Dimethylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] hydroiodide

수율 93.8%

용매

ethanol

methanol

반응 조건

후처리

1. 1
   온도under reflux overnight
2. 2
   기타Removal of the solvents

실험 절차

A solution of 2'-(N-methylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (5.9 g) and iodomethane (4.1 g) in ethanol (45 ml) and methanol (100 ml) is heated under reflux overnight. Removal of the solvents yields a solid (8.1 g). The solid (1.0 g) is twice recrystallized from ethyl acetate/methanol to yield 0.6 g (60%) of product as crystals, mp 181°-182°.

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