반응 #735283

반응 방정식

spiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

methylisothiocyanate

→

2'-(N-Methylthiocarbamyl)spiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

용매

benzene

benzene

반응 조건

후처리

1. 1
   기타to separate
2. 2
   workup.ADDITIONdiluted with hexane (18 ml)
3. 3
   여과The product is filtered
4. 4
   세척washed with hexane
5. 5
   기타dried
6. 6
   기타to yield a solid
7. 7
   기타The solid is twice recrystallized from benzene
8. 8
   기타to yield (3.0 g, 46%) as a solid, mp 165°-166°

실험 절차

To a stirred solution of spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (5.0 g) in dry benzene (18 ml) is added methylisothiocyanate (3.1 g) in dry benzene (10 ml). After one hour, the product begins to separate. The mixture is stirred overnight and diluted with hexane (18 ml). The product is filtered, washed with hexane and dried to yield a solid. The solid is twice recrystallized from benzene to yield (3.0 g, 46%) as a solid, mp 165°-166°.

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