반응 #735282

반응 방정식

spiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

3,5-dimethylpyrazole carboxamidine nitrate

→

product

수율 42.9%

2'-Amidinospiro[benzofuran-2(3H),4'(2'H)-isoquinoline] nitrate

수율 42.9%

용매

ethanol

반응 조건

후처리

1. 1
   온도under reflux for 7 hours
2. 2
   기타The mixture is evaporated to dryness in vacuo
3. 3
   기타the viscous residue is triturated with ether
4. 4
   여과After filtration
5. 5
   기타the precipitate is twice recrystallized from ethyl acetate/methanol

실험 절차

A solution of spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (4.2 g), 3,5-dimethylpyrazole carboxamidine nitrate (3.6 g) in 95% ethanol (80 ml) is heated under reflux for 7 hours. The mixture is evaporated to dryness in vacuo and the viscous residue is triturated with ether. After filtration, the precipitate is twice recrystallized from ethyl acetate/methanol to yield product (2.6 g, 42%) as a solid, mp 188°.

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