반응 #735280

반응 방정식

spiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

triethylamine

acetyl chloride

→

solid

수율 65.8%

2'-Acetylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

수율 65.8%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척the reaction mixture is washed with water (2x), saturated sodium chloride solution
2. 2
   건조dried over anhydrous magnesium sulfate
3. 3
   기타Removal of the solvent

실험 절차

To a cooled solution of spiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (8.0 g) and triethylamine (4.1 g) in dichloromethane (35 ml) is added dropwise acetyl chloride (3.2 g) in dichloromethane (20 ml). After stirring at ambient temperature for 20 hours, the reaction mixture is washed with water (2x), saturated sodium chloride solution and dried over anhydrous magnesium sulfate. Removal of the solvent yields a solid (6.2 g), of which 2.5 g is recrystallized from ethyl acetate to yield 1.4 g (56%) of product as a powder, mp 141°-142°.

출처