반응 #735278

반응 방정식

hexane

6-chloro-2'-methylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

phenyl chloroformate

→

product

수율 99.0%

6-Chloro-2'-phenoxycarbonylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

수율 99.0%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   기타Removal of the solvent in vacuo
2. 2
   기타yields an orange oil which
3. 3
   기타An analytical sample is twice recrystallized from hexane

실험 절차

To an ice cold solution of 6-chloro-2'-methylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (5.0 g) in dichloromethane (150 ml) is slowly added dropwise phenyl chloroformate (3.7 g) in dichloromethane (20 ml). The mixture is stirred at ambient temperature overnight. Removal of the solvent in vacuo yields an orange oil which solidifies upon trituration with hexane. An analytical sample is twice recrystallized from hexane to yield product as a solid (6.6 g, 99%), mp 138°-140°.

출처