반응 #735273

반응 방정식

2'-methylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

ethyl chloroformate

→

product

수율 76.0%

2'-Ethoxycarbonylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

수율 76.0%

용매

benzene

반응 조건

후처리

1. 1
   세척The reaction mixture is washed with water (3x), saturated sodium chloride solution
2. 2
   건조dried over anhydrous magnesium sulfate
3. 3
   여과After filtering
4. 4
   기타the solvent is removed

실험 절차

A solution of 2'-methylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (26.1 g) and ethyl chloroformate (12.4 g) is heated under reflux in benzene (275 ml) overnight. The reaction mixture is washed with water (3x), saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtering, the solvent is removed to yield 24 g (76%) of product as a solid, mp 65°-75°. A sample is thrice recrystallized from hexane to yield the product, mp 89°-90°.

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