반응 #735272

반응 방정식

N-methylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

phenylchloroformate

→

product

수율 69.7%

N-Phenoxycarbonylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline]

수율 69.7%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타Removal of the solvent
2. 2
   기타yields an oil
3. 3
   기타Trituration with n-propanol followed by recrystallization of 4.0 g of the solid
4. 4
   기타so formed from ethyl acetate

실험 절차

To a previously flamed 2000 ml round-bottom flask is added N-methylspiro[benzofuran-2(3H),4'(2'H)-isoquinoline] (32.5 g) in dichloromethane (700 ml). To this is added phenylchloroformate (20 ml). The mixture is stirred overnight. Removal of the solvent yields an oil. Trituration with n-propanol followed by recrystallization of 4.0 g of the solid so formed from ethyl acetate yields 2.6 g (69.7%) of product, mp 128°.

출처