반응 #7351
ord-2b0d9ce6dac1428494fdac9548bda8fb
반응 방정식
34b
4-Bromo-3-chloro-2-(3-fluoro-4-methoxyphenyl)-6-methoxyquinoline
Pyr
HCl
→
3-Chloro-4-cyano-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol
수율 41.0%
반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
This compound was prepared from 34b according to method F and method G (using Pyr./HCl). Yellow solid; Yield: 41% (for two steps); mp 325–328° C. (dec.); 1H-NMR (300 MHz, DMSO-d6) δ 7.10 (dd, J=8.8, 8.7 Hz, 1H), 7.27 (d, J=2.5 Hz, 1H), 7.43 (dd, J=8.4, 1.4 Hz, 1H), 7.49 (dd, J=9.2, 2.5 Hz, 1H), 7.55 (dd, J=12.2, 2.0 Hz, 1H), 8.04 (d, J=9.1 Hz, 1H), 10.37 (s, 1H), 10.97 (s, 1H); MS (ESI) m/z 313 ([M−H]−), 315 ([M+H]+); Anal. Calcd for C16H8ClFN2O2: C: 61.07, H: 2.56, N: 8.90. Found: C: 60.80, H: 2.57, N: 8.55.