반응 #73471

반응 방정식

1-[(1S,2S,4S)-5-(7-Chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

2-propanol

HCl

→

desired product

수율 100.4%

6-[(1S,4S,5S)-5-(1-Amino-propyl)-5-phenyl-bicyclo[2.2.1]hept-2-yloxy]-7-chloro-2H-isoquinolin-1-one

수율 100.4%

용매

water

반응 조건

후처리

1. 1
   기타the mixture freeze dried
2. 2
   workup.ADDITIONThe residue was once again treated with 20 mL of water and freeze
3. 3
   기타dried

실험 절차

35 mg of 1-[(1S,2S,4S)-5-(7-Chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine (90) were dissolved using 1 mL of 2-propanol and 1 mL of a 1N aqueous HCl-solution. The mixture was heated to 100° C. for 1 h under microwave irradiation. Afterwards, 20 mL of water were added and the mixture freeze dried. The residue was once again treated with 20 mL of water and freeze dried to yield 34 mg of the desired product as its hydrochloride. Rt=0.75 min (Method 18). Detected mass: 423.2 (M+H+)

출처