반응 #734460

반응 방정식

pyridine

myristic acid

2-bromoethyl phosphorodichloridate

3-(N-tridecylcarbamoyloxy)propanol

benzene

→

compound

3-(N-Tridecylcarbamoyloxy)propyl 2-trimethylammonioethyl phosphate

반응 조건

후처리

1. 1
   기타purified by silica gel chromatography

실험 절차

In 23 ml of benzene are dissolved 4.0 g (13.27 mM) of 3-(N-tridecylcarbamoyloxy)propanol prepared from 9.12 g of myristic acid as in Example 18 and 4.82 g (19.90 mM) of 2-bromoethyl phosphorodichloridate. To the solution is added dropwise 1.57 g (19.90 mM) of pyridine, and the mixture is stirred at room temperature. As in Example 20, the reaction mixture is hydrolyzed, converted to a quaternary ammonium compound, dehalogenated and purified by silica gel chromatography to give the contemplated compound as colorless solid. Yield 3.5 g.

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