반응 #73435

반응 방정식

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester

NCS

→

title compound

(4-Chloro-5-cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester

용매

AcOH

water

ethyl acetate

반응 조건

후처리

1. 1
   온도The reaction is cooled to room temperature
2. 2
   세척The organic layer is washed with 500 mL of water
3. 3
   기타to remove the acid
4. 4
   건조The organic layer is dried (sodium sulfate)
5. 5
   농축concentrated to an oil (352 mg)

실험 절차

(5-Cyclopropyl-isoxazol-3-yl)-carbamic acid phenyl ester (0.25 g, 1.024 mmol) is dissolved in AcOH (7.31 mL) and NCS (0.205 g, 1.53 mmol) is added and the reaction is heated to 79° C. for 2 hours. The reaction is cooled to room temperature and diluted with water and ethyl acetate. The organic layer is washed with 500 mL of water to remove the acid. The organic layer is dried (sodium sulfate) and concentrated to an oil (352 mg) to obtain the title compound that is used without further purification. MS (ESI) m/z 279.00 (M+1).

출처