반응 #73427

반응 방정식

1-methyl-1H-pyrazol-3-amine

acetonylacetone

water

water

→

3-(2,5-Dimethyl-pyrrol-1-yl)-1-methyl-1H-pyrazole

용매

toluene

AcOH

반응 조건

후처리

1. 1
   온도heated
2. 2
   농축Concentrated
3. 3
   기타to dry
4. 4
   기타The residue is purified by flash column
5. 5
   기타to give product

실험 절차

To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product.

출처