반응 #73358

반응 방정식

4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester

potassium tert-butoxide

→

(±)-1-Benzyl-2-methyl-3-oxo-piperidine-4-carboxylic acid methyl ester

용매

toluene

반응 조건

후처리

1. 1
   기타The mixture is then partitioned between DCM and saturated aqueous NH4Cl
2. 2
   기타The organic layer is removed
3. 3
   건조dried over anhydrous Na2SO4
4. 4
   농축concentrated
5. 5
   기타The crude residue is used without further purification

실험 절차

A mixture of 4-[benzyl-(1-ethoxycarbonyl-ethyl)-amino]-butyric acid methyl ester (1.5 g, 4.9 mmol), potassium tert-butoxide (906 mg, 8.9 mmol) and toluene (100 mL) is stirred at rt for 3 h. The mixture is then partitioned between DCM and saturated aqueous NH4Cl. The organic layer is removed, dried over anhydrous Na2SO4, and concentrated. The crude residue is used without further purification.

출처