반응 #7335

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9a

4-Cyano-6-methoxy-2-(4-methoxyphenyl)quinoline

Pyr

HBr

→

4-Cyano-2-(4-hydroxyphenyl)quinolin-6-ol

수율 89.0%

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실험 절차

This compound was prepared from 9a using Pyr./HBr according to method I. Yellow solid; Yield: 89%; mp>240° C. (dec.); 1H-NMR (300 MHz, DMSO-d6) δ 6.92 (d, J=8.7 Hz, 2H), 7.30 (d, J=2.6 Hz, 1H), 7.45 (dd, J=9.1, 2.6 Hz, 1H), 8.02 (d, J=9.1 Hz, 1H), 8.13 (d, J=8.7 Hz, 2H), 8.58 (s, 1H), 9.93 (s, 1H), 10.64 (s, 1H); MS (ESI) m/z 261 ([M−H]−), 263 ([M+H]+); Anal. Calcd for C16H10N2O2: C: 73.27, H: 3.84, N: 10.68. Found: C: 71.75, H: 3.86, N: 10.14.

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