반응 #733413

반응 방정식

4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole

1-bromo-3-ethynylbenzene

→

title compound

수율 99.5%

4-[(3-bromophenyl)ethynyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole

수율 99.5%

용매

triethylamine

acetonitrile

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   온도the reaction mixture is cooled
3. 3
   농축concentrated
4. 4
   기타The crude material is purified by chromatography (silica gel, EtOAc/hexane:5/95)

실험 절차

To a solution of 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole (4.14 g, 15 mmol) in triethylamine (53 mL) is added tetrakis(triphenylphosphine)paddadium (1.20 g, 1.04 mmol), copper iodide (0.28 g, 1.46 mmol) and a solution of 1-bromo-3-ethynylbenzene (2.78 g, 15 mmol) in acetonitrile (15 mL) at room temperature. After heating for 1 hour at 80° C., the reaction mixture is cooled and concentrated. The crude material is purified by chromatography (silica gel, EtOAc/hexane:5/95) to give the title compound as a solid (4.91 g, 99%). mp: 107-109° C. MS (+) EI: 328 M+.

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