반응 #7334

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3,5-difluoro-4-methoxyacetophenone

dimethyl carbonate

→

Methyl (3,5-difluoro-4-methoxybenzoyl)acetate

수율 97.0%

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실험 절차

This compound was prepared from 3,5-difluoro-4-methoxyacetophenone and dimethyl carbonate according to method A. Yellow solid; Yield: 97%; mp 64–67° C.; 1H-NMR (300 MHz, CDCl3) δ 3.77 (s, 3H), 3.93 (s, 2H), 4.13 (t, J=1.7 Hz, 3H), 7.52 (m, 2H). Minor tautomer: 3.81 (s, 3H), 4.06 (m, 3H), 5.58 (s, 1H), 7.34 (m, 2H), 12.47 (s, 1H); MS (ESI) m/z 243 ([M−H]−), 245 ([M+H]+); Anal. Calcd for C11H10F2O4: C: 54.10, H: 4.13. Found: C: 54.37, H: 4.08.

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