반응 #7326

반응 방정식

Pyridine

cyanuric fluoride

FMOC-L-Leucine

→

FMOC-L-leucyl fluoride

용매

acetonitrile

반응 조건

후처리

1. 1
   여과the resulting slurry was filtered
2. 2
   workup.ADDITIONThe filtrate was poured into a separatory funnel
3. 3
   기타the layers were separated
4. 4
   건조The organic layer was dried over anhydrous sodium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated under reduced pressure

실험 절차

FMOC-L-Leucine (5 g, 14.14 mmol) (Bachem) was dissolved in acetonitrile (70 mL). Pyridine (1.14 mL, 14.14 mmol) (Aldrich) and cyanuric fluoride (1.91 g, 14.14 mmol) (Aldrich) were successively added at room temperature and the mixture was stirred overnight. Ice cold water (300 mL) was added and the resulting slurry was filtered. The filtrate was poured into a separatory funnel and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford FMOC-L-leucyl fluoride as a white powder. (Yield 4.57 g, 91%).

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