반응 #7323

반응 방정식

Pyridine

cyanuric fluoride

FMOC-Glycine

→

FMOC-glycyl fluoride

용매

dichloromethane

반응 조건

후처리

1. 1
   여과the resulting slurry was filtered
2. 2
   workup.ADDITIONThe filtrate was poured into a separatory funnel
3. 3
   기타the layers were separated
4. 4
   건조The organic layer was dried over anhydrous sodium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated under reduced pressure

실험 절차

FMOC-Glycine (5.02 g, 16.82 mmol) (Bachem) was dissolved in dichloromethane (85 mL). Pyridine (1.36 mL, 16.82 mmol) (Aldrich) and cyanuric fluoride (2.27 g, 16.82 mmol) (Aldrich) were successively added at room temperature and the mixture was stirred overnight. Ice cold water (100 mL) was added and the resulting slurry was filtered. The filtrate was poured into a separatory funnel and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford FMOC-glycyl fluoride as a white powder. (Yield 3.67 g, 73%).

출처