반응 #73139

반응 방정식

(R)-2-(3-(aminomethyl)pyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one

TFA

→

title compound

(R)—N-((4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)pyridin-3-yl)methyl)acetamide

용매

acetic acid

반응 조건

실험 절차

The title compound was prepared similarly to the methods described in Example 102, with (R)-2-(3-(aminomethyl)pyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 105) instead of (R)-2-(3-aminopyridin-4-yl)-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one (Example 91), and with acetic acid instead of benzoic acid. LCMS (0.05% TFA): 409.2 m/z (M+H)+; 1H-NMR (CDCl3, 500 MHz): δ: 8.98 (bs, 1H), 8.82 (d, 1H, J=5.0 Hz), 8.39 (d, 1H, J=5.0 Hz), 8.05 (s, 1H), 7.31 (bs, 1H), 4.84 (s, 2H), 4.46 (m, 1H), 4.37 (m, 1H), 3.44 (s, 3H), 2.03 (m, 1H), 1.95 (s, 3H), 1.94˜1.68 (m, 9H), 0.91 (t, 3H, J=7.5 Hz).

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