반응 #7313

반응 방정식

1-(5-chlorobenzotriazol-1-yl)-propan-2-one

ethanol

sodium cyanide

ammonium chloride

→

2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile

용매

—

solution

ammonia

반응 조건

후처리

1. 1
   농축The reaction mixture is subsequently concentrated by evaporation in a vacuum
2. 2
   workup.DISSOLUTIONdissolved again in ethyl acetate
3. 3
   세척washed with water and saturated sodium chloride solution
4. 4
   기타The organic phase is separated
5. 5
   건조dried with magnesium sulphate
6. 6
   농축concentrated by evaporation

실험 절차

240 mg of 1-(5-chlorobenzotriazol-1-yl)-propan-2-one are dissolved in 4 ml of a 2-molar solution of ammonia in ethanol, then 64 mg of sodium cyanide and 91 mg of ammonium chloride are added and the mixture is stirred over night at room temperature. The reaction mixture is subsequently concentrated by evaporation in a vacuum, dissolved again in ethyl acetate, and washed with water and saturated sodium chloride solution. The organic phase is separated, dried with magnesium sulphate and concentrated by evaporation. 2-amino-3-(5-chlorobenzotriazol-1-yl)-2-methylpropionitrile is thus obtained.

출처