반응 #731290

반응 방정식

3-(4-fluorophenyl)-1-isopropyl-1H-indole

methyl trans-3-methoxyacrylate

hydrogen bromide acetic acid

→

methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate

수율 8.9%

용매

acetic acid

반응 조건

후처리

1. 1
   기타a reaction
2. 2
   기타After completion of the reaction

실험 절차

1.27 g of 3-(4-fluorophenyl)-1-isopropyl-1H-indole, 1.16 g of methyl trans-3-methoxyacrylate and 12 mL of glacial acetic acid were mixed, then, 797 mg of 30 wt % hydrogen bromide/acetic acid solution was added dropwise into the mixture at an inner temperature of 25° C., the mixture was stirred for 5 hours at the same temperature to cause a reaction. After completion of the reaction, the same post treatment was conducted as in Example 1 to obtain 0.15 g of methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). Yield: 8%.

출처