반응 #731287

반응 방정식

phosphorus oxychloride

3-(4-fluorophenyl)-1-isopropyl-1H-indole

methyl trans-3-methoxyacrylate

water

→

methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate

수율 79.0%

용매

acetic acid

반응 조건

후처리

1. 1
   기타a reaction
2. 2
   기타After completion of the reaction

실험 절차

0.62 g of 3-(4-fluorophenyl)-1-isopropyl-1H-indole, 0.57 g of methyl trans-3-methoxyacrylate, 46 mg of water and 6.4 mL of glacial acetic acid were mixed, then, 66 mg of phosphorus oxychloride was added dropwise into the mixture at an inner temperature of 25° C., the added mixture was stirred for 21 hours at the same temperature to cause a reaction. After completion of the reaction, the same post treatment was conducted as in Example 1 to obtain 0.65 g of methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). Yield: 79%.

출처