반응 #73036

반응 방정식

Sodium carbonate

alanine ethyl ester hydrochloride

benzyl bromide

acetonitrile

→

ethyl 3-dibenzylaminopropionate

반응 조건

후처리

1. 1
   여과filtered through a layer of CELITE
2. 2
   여과filter aid
3. 3
   세척The filter cake was rinsed with acetonitrile (100 mL)
4. 4
   농축The filtrate was concentrated under reduced pressure

실험 절차

Sodium carbonate (21.1 g, 199 mmol) was added to a suspension of fl-alanine ethyl ester hydrochloride (10.2 g, 66.4 mmol) and benzyl bromide (16.2 mL, 136 mmol) in acetonitrile (265 mL). The reaction mixture was stirred at ambient temperature overnight and then filtered through a layer of CELITE filter aid. The filter cake was rinsed with acetonitrile (100 mL). The filtrate was concentrated under reduced pressure to provide 20.28 g of ethyl 3-dibenzylaminopropionate as a pale yellow oil.

출처