반응 #73031

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4-[(3-nitro[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol

→

4-[(3-amino[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol

수율 115.1%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타for 3 hours
2. 2
   여과The reaction mixture was filtered through a layer of CELITE
3. 3
   여과filter aid
4. 4
   세척the filter cake was rinsed with 1:1 ethyl acetate
5. 5
   농축The filtrate was concentrated under reduced pressure

실험 절차

A mixture of 4-[(3-nitro[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol (12.2 g), 5% platinum on carbon (1.22 g), and ethyl acetate (160 mL) was placed under hydrogen pressure (40 psi, 2.8×105 Pa) for 3 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with 1:1 ethyl acetate:methanol (150 mL). The filtrate was concentrated under reduced pressure to provide 12.66 g of 4-[(3-amino[1,5]naphthyridin-4-ylamino)methyl]tetrahydropyran-4-ol as a thick semi-solid.

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