반응 #73029

반응 방정식

Triethylorthopropionate

pyridine hydrochloride

4-[(3-aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol

→

4-[(2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]tetrahydro-2H-pyran-4-ol

용매

toluene

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도at reflux for 2.5 hours
3. 3
   농축concentrated under reduced pressure
4. 4
   기타The residue was triturated with acetonitrile
5. 5
   여과the filtered

실험 절차

Triethylorthopropionate (2.4 mL, 12.0 mmol) and pyridine hydrochloride (60 mg, 0.5 mmol) were added to a suspension of 4-[(3-aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol (10.0 mmol) in toluene (50 mL). The reaction mixture was heated at reflux for 2.5 hours and then concentrated under reduced pressure. The residue was triturated with acetonitrile and the filtered to provide 4-[(2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]tetrahydro-2H-pyran-4-ol as a tan solid.

출처