반응 #73027

반응 방정식

Trimethylorthovalerate

pyridine hydrochloride

4-[(3-aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol

→

4-[(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]tetrahydro-2H-pyran-4-ol

용매

toluene

반응 조건

후처리

1. 1
   온도The reaction mixture was heated
2. 2
   온도at reflux for 2.5 hours
3. 3
   기타A precipitate was isolated by filtration
4. 4
   기타dried

실험 절차

Trimethylorthovalerate (1.8 mL, 10.4 mmol) and pyridine hydrochloride (92 mg, 0.8 mmol) were added to a suspension of 4-[(3-aminoquinolin-4-ylamino)methyl]tetrahydropyran-4-ol (8.0 mmol) in toluene (40 mL). The reaction mixture was heated at reflux for 2.5 hours and then cooled to ambient temperature. A precipitate was isolated by filtration and dried to provide 4-[(2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]tetrahydro-2H-pyran-4-ol as a white solid, mp 180-181° C. MS (ESI) m/z 340 (M+H)+; Anal. calcd for C20H25N3O2: C, 70.77; H, 7.42; N, 12.38. Found: C, 70.58; H, 7.53; N, 12.40.

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