반응 #72925

반응 방정식

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

diethylether

→

title compound

수율 92.0%

N′-(1-acetylpiperidin-4-yl)benzohydrazide

수율 92.0%

용매

acetic acid

반응 조건

후처리

1. 1
   여과The catalyst was then filtered on celite
2. 2
   기타the filtrate evaporated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was redissolved with dichloromethane
4. 4
   세척washed with aqueous NaHCO3
5. 5
   건조The solvent was dried over sodium sulfate
6. 6
   기타removed under reduced pressure
7. 7
   기타to give

실험 절차

30 g (0.12 mol) of N′-(1-acetylpiperidin-4-ylidene)benzohydrazide were dissolved in 500 mL of glacial acetic acid and 1 g of PtO2 were added. The mixture was hydrogenated at 40 psi for 12 hours at room temperature. The catalyst was then filtered on celite and the filtrate evaporated in vacuo. The residue was redissolved with dichloromethane and washed with aqueous NaHCO3. The solvent was dried over sodium sulfate and removed under reduced pressure to give, after trituration with diethylether, 28.6 g (92% yield) of the title compound.

출처