반응 #72924

반응 방정식

diethylether

1-acetyl-4-piperidone

benzoylhydrazine

→

title compound

수율 83.0%

N′-(1-acetylpiperidin-4-ylidene)benzohydrazide

수율 83.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도The resulting solution was refluxed for 6 hours
2. 2
   기타The solvent was then removed in vacuo
3. 3
   기타the residue partitioned between dichloromethane and water
4. 4
   건조The organic layer was dried over sodium sulfate
5. 5
   기타evaporated to dryness

실험 절차

20 g (0.142 mol) of 1-acetyl-4-piperidone were dissolved in 400 mL of absolute ethanol and 21.2 g (0.156 mol) of benzoylhydrazine were added. The resulting solution was refluxed for 6 hours under stirring. The solvent was then removed in vacuo and the residue partitioned between dichloromethane and water. The organic layer was dried over sodium sulfate and evaporated to dryness. The residue was triturated with diethylether and 30 g (83% yield) of the title compound were collected by filtration.

출처