반응 #72791

반응 방정식

2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Tetrahydrofuran

lithium hydroxide

→

product

수율 66.0%

1-[(3,4-dimethylphenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acid

수율 66.0%

반응 조건

후처리

1. 1
   온도The reaction was cooled to room temperature
2. 2
   기타The organic solvent was removed in-vacuo
3. 3
   여과The precipitate was collected by filtration
4. 4
   workup.ADDITIONWater (20 mL) was added in
5. 5
   여과The resulting solid was filtered
6. 6
   세척washed with water
7. 7
   기타dried

실험 절차

To a mixture of methyl 1-[3,4-dimethylphenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate (0.24 g, 0.61 mmol) in Tetrahydrofuran (THF) (10 mL) was added in lithium hydroxide (5.99 mL, 11.99 mmol). The reaction was stirred at 50° C. for 2 h. The reaction was cooled to room temperature. The organic solvent was removed in-vacuo. The precipitate was collected by filtration. Water (20 mL) was added in. The mixture was acidified with 1 N HCl. The resulting solid was filtered and washed with water and dried to give the product (0.16 g, 66%). 1H NMR (400 MHz, DMSO-d6) δ ppm 2.18 (s, 6H), 2.58-2.75 (s, 3H), 3.06-3.22 (m, 4H), 3.71-3.82 (m, 4H), 5.55 (s, 2H), 6.94 (m, 1H), 7.04 (s, 1H), 7.11 (d, 1H, J=7.83 Hz), 7.52 (m, 2H). MS (ES+) m/e 380.2[M+H]+

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