반응 #727696

반응 방정식

sodium hydrogencarbonate

2-(4-[1,3]dioxolan-2-yl-3-fluoro-benzyloxy)-pyridine

tetrahydrofuran

hydrochloric acid

→

title compound

수율 99.3%

2-Fluoro-4-(pyridin-2-yloxymethyl)-benzaldehyde

수율 99.3%

용매

methanol

반응 조건

후처리

1. 1
   온도This mixture was cooled to 0° C.
2. 2
   추출after which it was extracted with ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   세척washed with water
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   여과filtered
7. 7
   농축The filtrate was concentrated under a reduced pressure

실험 절차

To a solution of 2-(4-[1,3]dioxolan-2-yl-3-fluoro-benzyloxy)-pyridine (2.17 g, 7.88 mmol) described in Manufacturing Example 204-1-4 in methanol (10 mL) and tetrahydrofuran (10 mL) was added 5 N hydrochloric acid (8.43 mL, 8.43 mmol). This solution was stirred for 15 minutes at room temperature. This mixture was cooled to 0° C. and neutralized with a saturated sodium hydrogencarbonate aqueous solution, after which it was extracted with ethyl acetate. The organic layer was separated, washed with water, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure to obtain the title compound (1.81 g). The title compound was used in the following reaction without any further purification.

출처