반응 #72761

반응 방정식

6-bromo-2-(1-methylethyl)-1-(1-naphthalenylmethyl)-4-nitro-1H-benzimidazole

morpholine

Cs2CO3

X-Phos

→

desired product

수율 77.0%

2-(1-methylethyl)-6-(4-morpholinyl)-1-(1-naphthalenylmethyl)-4-nitro-1H-benzimidazole

수율 77.0%

용매

dioxane

반응 조건

후처리

1. 1
   기타was degassed with nitrogen
2. 2
   온도The mixture was cooled to room temperature
3. 3
   기타the solvent was removed in-vacuo
4. 4
   기타The residue was then purified by silica gel chromatography
5. 5
   세척eluted with (EtOAc:petroleum ether=1:1)

실험 절차

A mixture of 6-bromo-2-(1-methylethyl)-1-(1-naphthalenylmethyl)-4-nitro-1H-benzimidazole (2.05 g), morpholine (1.26 g), Pd2(dba)3 (0.46 g), Cs2CO3 (2.36 g) and X-Phos (0.41 g) in dioxane (30 mL) was degassed with nitrogen and then stirred at 80° C. overnight. The mixture was cooled to room temperature and the solvent was removed in-vacuo. The residue was then purified by silica gel chromatography eluted with (EtOAc:petroleum ether=1:1) to afford the desired product as a yellow solid (1.6 g, 77%). LC-MS: m/e=431 [M+1]+

출처